Dysplastic nevus
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Dysplastic nevi – e fautuaina le biopsy i tagata papalagi.
relevance score : -100.0%
ReferencesDysplastic nevus, ua lauiloa foi o se atypical poʻo Clarks nevus, ua faʻaoso felafolafoaiga i dermatology ma dermatopathology. E masani ona su'esu'e e foma'i nei mole ona e foliga mai e le masani ma fa'atupu ai popolega e uiga i le melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi, e taʻua foʻi o le atypical poʻo Clark nevi, e mafai i nisi taimi ona oʻo atu i le melanoma. E tusa ma le 36% o melanomas e maua i tafatafa o le dysplastic nevi. O fa'ailoga e mafai ona liua le nevus dysplastic i le melanoma e aofia ai foliga le tutusa, tele suiga o le pigmenti, po'o se lanu efuefu. O nei kanesa e masani ona tupu i le la'ititi o tausaga (e tusa ma le ogatotonu o le tolusefulu), e mafai ona tele, ma e masani ona i luga o le ogalaau. I le fa'aleaga, dysplastic nevi o lo'o i le va o nevi mama ma le melanoma. Ae peita'i, e na'o le 20% i le 30% o melanomas e sau mai nevi o iai. Talu ai o le tele o nevi e le avea ma melanoma, e masani lava e le fautuaina e aveese ma puipuia.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
O le melanoma o se ituaiga tuma e tupu pe a avea melanocytes, o sela e nafa ma le lanu o le paʻu, ma kanesa. Melanocytes e afua mai i le neural crest. O lona uiga e le gata e mafai ona tupu le melanoma i luga o le paʻu, ae faapena foʻi i isi vaega o lo’o feoai ai sela o le neural crest, e pei o le gastrointestinal tract ma le faiʻai. O le fua faatatau o le ola mo tagata mamaʻi i le amataga o le melanoma (laasaga 0) e maualuga i le 97 %, ae e pa'ū tele i le tusa ma le 10 % mo i latou o lo’o i le tulaga maualuga (tulaga IV).
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Aafiaga o le kanesa
E pei ona vaaia i tagata Caucasian i le Iunaite Setete, o i latou o lo’o iai dysplastic nevi, e iai le lamatiaga i le olaga atoa o le atiaʻe le melanoma e sili atu i le 10 %. I le isi itu, i tagata e le’i iai dysplastic nevi, e itiiti le lamatiaga o le atiaʻe le melanoma i le 1 %.
○ Lapataiga mo tagata o lo’o iai dysplastic nevi
E masani ona fautuaina le su’esu’eina o le pa’u mo le puipuia o le melanoma (e ala i le iloa o nevi atypical e mafai ona aveese) po’o le vave iloa o tuma o iai. O tagata e iai tala fa’asolo‑pito o le tagata lava ia po’o le aiga, po’o le tele o nevi atypical, e tatau ona feiloaʻi ma le fomaʻi i le taimi vave ma i le tausaga e fa’ataunu’u ai le auiliili, ina ia mautinoa e le atiaʻe le melanoma.
O le fa’apu’upu’u [ABCDE] na aoga mo le fesoasoani i le au tausi soifua ma tagata ta’ita’i e manatua uiga autu o le ma’i. Peita’i mo le tagata lautele, o le tele o seborrheic keratoses, nisi lentigo senilis, ma warts atonu e iai uiga [ABCDE], ma e le mafai ona fa’ailoa i le melanoma.
○ [ABCDE]
Asymmetrical: Pa’u e le tutusa.
Border: Tuaoi e le masani.
Color: Melanomas e masani ona iai lanu e le tutusa po’o le lanu fa’aletonu.
Diameter: Nevi e sili atu i le 6 mm e mafai ona fa’ailoa i le melanoma nai lo nevi laiti.
Evolution: O le suiga (e pei o le evolusione) o se nevus poʻo se ma’i e mafai ona fa’aalia ai le fa’atauga o le melanoma.